Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is associated with impaired aerobic capacity. We investigated the integrity of cardiac β-receptor responsiveness, an important mechanism involved in exertional increases in HR, in HFpEF and control subjects.

Methods

Thirteen carefully screened patients with HFpEF and 13 senior controls underwent exercise testing and graded isoproterenol infusion to quantify cardiac β-receptor-mediated HR responses. To limit autonomic neural influences on heart rate (HR) during isoproterenol, dexmedetomidine and glycopyrrolate were given. Isoproterenol doses were increased incrementally until HR increased by 30 beats per minute. Plasma levels of isoproterenol at each increment were mea

SUBMITTER: Sarma S 

PROVIDER: S-EPMC7347285 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature