Advanced single voxel ¹ H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations.

ABSTRACT: Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite changes, the limitations of vendor-provided MRS protocols are increasingly recognized, especially when used at high fields (≥3 T) where chemical shift displacement errors, B₀ and B₁ inhomogeneities and limitations in the transmit B₁ field become prominent. To overcome the limitations of conventional MRS protocols at 3 and 7 T, the use of advanced MRS methodology, including pulse sequences and adjustment procedures, is recommended. Specifically, the semiadiabatic LASER sequence is recommended when T_E

SUBMITTER: Oz G 

PROVIDER: S-EPMC7347431 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature