Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis.

ABSTRACT: Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical an

SUBMITTER: Oliveira-de-Souza D 

PROVIDER: S-EPMC7347549 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature