Simplified modeling of E. coli mortality after genome damage induced by UV-C light exposure.

ABSTRACT: UV light is a group of high-energy waves from the electromagnetic spectrum. There are three types of UV radiations: UV-A, -B and -C. UV-C light are the highest in energy, but most are retained by the ozone layer. UV-A and -B reach the earth's surface and cause damage on living organisms, being considered as mutagenic physical agents. Numerous test models are used to study UV mutagenicity; some include special lamps, cell cultures and mathematical modeling. Mercury lamps are affordable and useful sources of UV-C light due to their emission at near the maximum absorption peak of nucleic acids. E. coli cultures are widely used because they have DNA-damage and -repairing mechanisms fairly similar to humans. In here we present two simple models that describe UV-C light incidence on a genome mat

SUBMITTER: Sanchez-Navarrete J 

PROVIDER: S-EPMC7347587 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature