Ontology highlight
ABSTRACT:
SUBMITTER: Zhong L
PROVIDER: S-EPMC7347714 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zhong Lintao L He Xiang X Song Haoyu H Sun Yili Y Chen Guojun G Si Xiaoyun X Sun Jie J Chen Xiaoqiang X Liao Wangjun W Liao Yulin Y Bin Jianping J
Molecular therapy. Nucleic acids 20200610
Identifying effective drugs to delay the progression of aortic aneurysms is a formidable challenge in vascular medicine. Methyltransferase-like 3 (METTL3) plays a key role in catalyzing the formation of N6-methyladenosine (m<sup>6</sup>A), but despite the functional importance of METTL3 and m<sup>6</sup>A in various fundamental biological processes, their roles in abdominal aortic aneurysm (AAA) are unknown. Here, we found that METTL3 knockdown in apolipoprotein E-deficient (ApoE<sup>-/-</sup>) ...[more]