Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses.

ABSTRACT: AhR is a ligand-activated transcription factor that plays an important role in the innate and adaptive immune responses. In infection models, it has been associated with host responses that promote or inhibit disease progression. In pulmonary paracoccidioidomycosis, a primary fungal infection endemic in Latin America, immune protection is mediated by Th1/Th17 cells and disease severity with predominant Th2/Th9/Treg responses. Because of its important role at epithelial barriers, we evaluate the role of AhR in the outcome of a pulmonary model of paracoccidioidomycosis. AhR^-/- mice show increased fungal burdens, enhanced tissue pathology and mortality. During the infection, AhR^-/- mice have more pulmonary myeloid cells with activated phenotype and reduced numbers expres

SUBMITTER: de Araujo EF 

PROVIDER: S-EPMC7347857 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature