Regional transcriptome analysis of AMPA and GABA_A receptor subunit expression generates E/I signatures of the human brain.

ABSTRACT: Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brain disorders. Over recent years, large amount of microarray and RNA-Sequencing datasets have been collected, however few studies have made use of these resources for exploring the balance of global gene expression levels between excitatory AMPA receptors (AMPARs) and inhibitory GABA_A receptors. Here, we analyzed the relative relationships between these receptors to generate a basic transcriptional marker of E/I ratio. Using publicly available data from the Allen Brai

SUBMITTER: Shen K 

PROVIDER: S-EPMC7347860 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature