Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors.

ABSTRACT: Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary functions are exerted in different cellular compartments. Transcription factors (TFs) and splicing factors (SFs) control processes that occur in interphase nuclei and are strongly reduced during cell division, and are therefore in a favorable situation to evolve moonlighting mitotic functions. However, recently published moonlighting protein databases, which comprise almost 400 proteins, do not include TFs and SFs with secondary mitotic functions. We searched the literature and found several TFs and SFs with bona fide moonlighting mitotic f

SUBMITTER: Somma MP 

PROVIDER: S-EPMC7348712 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature