Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers.

ABSTRACT: γδ T-cells contribute to the immune response against many tumor types through their direct cytolytic functions and their capacity to recruit and regulate the biological functions of other immune cells. As potent effectors of the anti-tumor immune response, they are considered an attractive therapeutic target for immunotherapies, but their presence and abundance in the tumor microenvironment are not routinely assessed in patients with cancer. Here, we validated an antibody for immunohistochemistry analysis that specifically detects all γδ T-cell subpopulations in healthy tissues and in the microenvironment of different cancer types. Tissue microarray analysis of breast, colon, ovarian, and pancreatic tumors showed that γδ T-cell density varies among cancer types. Moreover, the abundance of

SUBMITTER: Chabab G 

PROVIDER: S-EPMC7348937 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature