The S1P-S1PR Axis in Neurological Disorders-Insights into Current and Future Therapeutic Perspectives.

ABSTRACT: Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena. Studies have highlighted its importance regarding intracellular signaling cascades as well as membrane-bound S1P receptor (S1PR) engagement in various clinical conditions. In neurological disorders, the S1P-S1PR axis is acknowledged in neurodegenerative, neuroinflammatory, and cerebrovascular disorders. Modulators of S1P signaling have enabled an immense insight into fundamental pathological pathways, which were pivotal in identifying and improving the treatment of human diseases. However, its intricate molecular signaling pathways initiated upon receptor ligation are still poorly elucidated. In this review, the authors highlight the cur

SUBMITTER: Lucaciu A 

PROVIDER: S-EPMC7349054 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature