Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models.

ABSTRACT: Chikungunya virus (CHIKV), Ross River virus (RRV), o'nyong nyong virus (ONNV), Mayaro virus (MAYV) and Getah virus (GETV) represent arthritogenic alphaviruses belonging to the Semliki Forest virus antigenic complex. Antibodies raised against one of these viruses can cross-react with other serogroup members, suggesting that, for instance, a CHIKV vaccine (deemed commercially viable) might provide cross-protection against antigenically related alphaviruses. Herein we use human alphavirus isolates (including a new human RRV isolate) and wild-type mice to explore whether infection with one virus leads to cross-protection against viremia after challenge with other members of the antigenic complex. Persistently infected Rag1^-/- mice were also used to assess the cross-protective capaci

SUBMITTER: Nguyen W 

PROVIDER: S-EPMC7349283 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature