Sex Chromosomes and Sex Phenotype Contribute to Biased DNA Methylation in Mouse Liver.

ABSTRACT: Sex biases in the genome-wide distribution of DNA methylation and gene expression levels are some of the manifestations of sexual dimorphism in mammals. To advance our understanding of the mechanisms that contribute to sex biases in DNA methylation and gene expression, we conducted whole genome bisulfite sequencing (WGBS) as well as RNA-seq on liver samples from mice with different combinations of sex phenotype and sex-chromosome complement. We compared groups of animals with different sex phenotypes, but the same genetic sexes, and vice versa, same sex phenotypes, but different sex-chromosome complements. We also compared sex-biased DNA methylation in mouse and human livers. Our data show that sex phenotype, X-chromosome dosage, and the presence of Y chromosome shape the differences in DN

SUBMITTER: Zhuang QK 

PROVIDER: S-EPMC7349295 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature