Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells.

ABSTRACT: Human phosphoantigen-reactive Vγ9Vδ2 T cells possess several characteristics, including MHC-independent recognition of tumor cells and potent killing potential, that make them attractive candidates for cancer immunotherapeutic approaches. Injectable preparations from the hemi-parasite plant Viscum album L. (European mistletoe) are commonly prescribed as complementary cancer therapy in European countries such as Germany, but their mechanism of action remains poorly understood. Here, we investigated in-depth the in vitro response of human T cells towards mistletoe-extract drugs by analyzing their functional and T-cell-receptor (TCR) response using flow cytometry and high-throughput sequencing respectively. Non-fermented mistletoe-extract drugs (AbnobaViscum), but not their fermented c

SUBMITTER: Ma L 

PROVIDER: S-EPMC7349316 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature