Do Genes Associated with Dyslexia of Chinese Characters Evolve Neutrally?

ABSTRACT: Dyslexia, or reading disability, is found to have a genetic basis, and several related genes have been reported. We investigated whether natural selection has acted on single nucleotide polymorphisms (SNPs) that were reported to be associated with risk/non-risk for the reading disability of Chinese characters. We applied recently developed 2D SFS-based statistics to SNP data of East Asian populations to examine whether there is any sign of selective sweep. While neutrality was not rejected for most SNPs, significant signs of selection were detected for two linkage disequilibrium (LD) regions containing the reported SNPs of GNPTAB and DCDC2. Furthermore, we searched for a selection target site among the SNPs in these LD regions, because a causal site is not necessarily a repor

SUBMITTER: Nishiyama KV 

PROVIDER: S-EPMC7349701 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature