Sexual Differentiation Is Coordinately Regulated by Cryptococcus neoformans CRK1 and GAT1.

ABSTRACT: The heterothallic basidiomycetous fungus Cryptococcus neoformans has two mating types, MATa and MATα. Morphological progression of bisexual reproduction in C. neoformans is as follows: yeast to hyphal transition, filament extension, basidium formation, meiosis, and sporulation. C. neoformans Cdk-related kinase 1 (CRK1) is a negative regulator of bisexual mating. In this study, we characterized the morphological features of mating structures in the crk1 mutant and determined the genetic interaction of CRK1 in the regulatory networks of sexual differentiation. In the bilateral crk1 mutant cross, despite shorter length of filaments than in the wild-type cross, dikaryotic filaments and other structures still remained intact

SUBMITTER: Liu KH 

PROVIDER: S-EPMC7349709 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature