Is an Increased Risk of Developing Guillain-Barre Syndrome Associated with Seasonal Influenza Vaccination? A Systematic Review and Meta-Analysis.

ABSTRACT: While the weight of epidemiological evidence does not support a causal link with influenza vaccination evaluated over the last 30 years, Guillain-Barré syndrome (GBS) has been considered a vaccine-associated adverse event of interest since 1976. To investigate the existence of GBS risk after vaccination against seasonal influenza, a systematic review and meta-analysis have been conducted based on 22 eligible epidemiological studies from 1981 to 2019 reporting 26 effect sizes (ESs) in different influenza seasons. The primary result of our meta-analysis pointed to no risk of vaccine-associated GBS, as documented by a pooled ES of 1.15 (95% CI: 0.97-1.35). Conversely, an obvious high risk of GBS was observed in patients with previous influenza-like illness (ILI), as demonstrated by a pooled E

SUBMITTER: Petras M 

PROVIDER: S-EPMC7349742 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature