Remodeling of the Histoplasma Capsulatum Membrane Induced by Monoclonal Antibodies.

ABSTRACT: Antibodies play a central role in host immunity by directly inactivating or recognizing an invading pathogen to enhance different immune responses to combat the invader. However, the cellular responses of pathogens to the presence of antibodies are not well-characterized. Here, we used different mass spectrometry techniques to study the cellular responses of the pathogenic fungus Histoplasma capsulatum to monoclonal antibodies (mAb) against HSP60, the surface protein involved in infection. A proteomic analysis of H. capsulatum yeast cells revealed that mAb binding regulates a variety of metabolic and signaling pathways, including fatty acid metabolism, sterol metabolism, MAPK signaling and ubiquitin-mediated proteolysis. The regulation of the fatty acid metabolism was accompa

SUBMITTER: Burnet MC 

PROVIDER: S-EPMC7349930 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature