Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males.

ABSTRACT:

Background and aims

Atherosclerosis is an important contributing factor to cardiovascular mortality. The role of Helicobacter pylori (H. pylori) infection in atherosclerosis is inconsistent and sometimes controversial. The present study aimed to determine if H. pylori infection is associated with carotid atherosclerosis.

Methods

17,613 males and females with both carotid ultrasonic examination and ¹³C-urea breath test for H. pylori infection were screened by a major Chinese university hospital from March 2012 to March 2017 for the study. Baseline demographics, cardiac risk factors, and laboratory studies were obtained. After exclusion for pre-specified conditions, 12,836 individuals were included in the analysis, including 8157 men (63.5%) and 4679 women (36.5%).

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7349937 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature