Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells.

ABSTRACT: Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, their implication with regard to vaccine responsiveness is insufficiently assessed. Therefore, this study aimed at the validation of essential NK cell features potentially associated with differential vaccine responsiveness with a special focus on NKG2C- and/or CD57-expressing NK cells considered to harbor memory-like functions. To this end, 16 healthy volunteers were vaccinated with an adjuvanted pandemic influenza vaccine. Vaccine responders and low responders were classified according to their hemagglutination inhibition antibody titers. A majority of responders dis

SUBMITTER: Riese P 

PROVIDER: S-EPMC7349951 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature