A Pool of Eight Virally Vectored African Swine Fever Antigens Protect Pigs Against Fatal Disease.

ABSTRACT: Classical approaches to African swine fever virus (ASFV) vaccine development have not been successful; inactivated virus does not provide protection and use of live attenuated viruses generated by passage in tissue culture had a poor safety profile. Current African swine fever (ASF) vaccine research focuses on the development of modified live viruses by targeted gene deletion or subunit vaccines. The latter approach would be differentiation of vaccinated from infected animals (DIVA)-compliant, but information on which viral proteins to include in a subunit vaccine is lacking. Our previous work used DNA-prime/vaccinia-virus boost to screen 40 ASFV genes for immunogenicity, however this immunization regime did not protect animals after challenge. Here we describe the induction of both antige

SUBMITTER: Goatley LC 

PROVIDER: S-EPMC7349991 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature