Specificity of CD8⁺ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya.

ABSTRACT: Sub-Saharan Africa carries the biggest burden of the human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need of an effective vaccine. CD8⁺ T cells are an important component of the host immune response to HIV-1 and may need to be harnessed if a vaccine is to be effective. CD8⁺ T cells recognize human leukocyte antigen (HLA)-associated viral epitopes and the HLA alleles vary significantly among different ethnic groups. It follows that definition of HIV-1-derived peptides recognized by CD8⁺ T cells in the geographically relevant regions will critically guide vaccine development. Here, we study fine details of CD8⁺ T-cell responses elicited in HIV-1/2-uninfected individuals in Nairobi, Kenya, who received a candidate vacci

SUBMITTER: Mohamed YS 

PROVIDER: S-EPMC7349992 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature