Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke.

ABSTRACT:

Objective

The CYP2C19 genetic variation may be involved in the development of atherosclerotic cardiovascular disease (ASCVD). Serum lipid levels are important risk factors for ASCVD, but the effect of the CYP2C19 gene on serum lipid metabolism remains unclear. This retrospective cohort study investigated the relationship between the CYP2C19 gene polymorphism and serum lipid levels in patients with ischemic stroke (IS).

Methods

IS patients (n = 230) and control subjects (n = 100) were enrolled. All patients were diagnosed with IS via clinical manifestations and brain magnetic resonance imaging. All patients were genotyped.

Results

Triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and apolipoprotein B (ApoB) levels were significantl

SUBMITTER: Bai Y 

PROVIDER: S-EPMC7350049 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature