The Mast Cell-SCF-CB1 Interaction Is a Key Player in Seborrheic Keratosis.

ABSTRACT: Mast cell (MC) is an important player in the development of skin diseases, including atopic dermatitis, psoriasis, and urticaria. It is reported that MC infiltration and activation are observed around various types of tumors and speculated that MCs play key roles in their pathogenesis. As MCs in human seborrheic keratosis (SK) have not been well investigated, here we focused on the MCs in SK. The number of c-Kit and tryptase-positive MCs was significantly increased around the SK compared with the marginal lesion. Degranulated MCs were also increased around the tumors. Furthermore, MC growth factor, stem cell factor (SCF), expression within the SK was significantly upregulated compared with the marginal lesion. Interestingly, one of the cognitive regulators of SCF expression, cannabinoid re

SUBMITTER: Yamanaka-Takaichi M 

PROVIDER: S-EPMC7350081 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature