Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G.

ABSTRACT: Respiratory syncytial virus (RSV) infections are a major cause of serious respiratory disease in infants. RSV occurs as two major subgroups A and B, which mainly differ regarding the surface glycoprotein G. The G protein is important for virus attachment and G-specific antibodies can protect against infection. We expressed the surface-exposed part of A2 strain-derived G (A2-G) in baculovirus-infected insect cells and synthesized overlapping peptides spanning complete A2-G. The investigation of the natural IgG response of adult subjects during a period of one year showed that IgG antibodies (i) recognize G significantly stronger than the fusion protein F0, (ii) target mainly non-conformational, sequential peptide epitopes from the exposed conserved region but also buried peptides, and (iii)

SUBMITTER: Borochova K 

PROVIDER: S-EPMC7350215 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature