Innate Immune Response against Hepatitis C Virus: Targets for Vaccine Adjuvants.

ABSTRACT: Despite successful treatments, hepatitis C virus (HCV) infections continue to be a significant world health problem. High treatment costs, the high number of undiagnosed individuals, and the difficulty to access to treatment, particularly in marginalized susceptible populations, make it improbable to achieve the global control of the virus in the absence of an effective preventive vaccine. Current vaccine development is mostly focused on weakly immunogenic subunits, such as surface glycoproteins or non-structural proteins, in the case of HCV. Adjuvants are critical components of vaccine formulations that increase immunogenic performance. As we learn more information about how adjuvants work, it is becoming clear that proper stimulation of innate immunity is crucial to achieving a successfu

SUBMITTER: Sepulveda-Crespo D 

PROVIDER: S-EPMC7350220 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature