Transcriptomic Analysis of the Early Strobilar Development of Echinococcus granulosus.

ABSTRACT: Echinococcus granulosus has a complex life cycle involving two mammalian hosts. The transition from one host to another is accompanied by changes in gene expression, and the transcriptional events that underlie this transition have not yet been fully characterized. In this study, RNA-seq was used to compare the transcription profiles of samples from E. granulosus protoscoleces induced in vitro to strobilar development at three time points. We identified 818 differentially expressed genes, which were divided into eight expression clusters formed over the entire 24 h period. An enrichment of gene transcripts with molecular functions of signal transduction, enzymes, and protein modifications was observed upon induction and developmental progression. This transcriptomic study pro

SUBMITTER: Debarba JA 

PROVIDER: S-EPMC7350322 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature