RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization.

ABSTRACT:

Background

Female infertility is a worldwide concern and the etiology of infertility has not been thoroughly demonstrated. Although the mouse is a good model system to perform functional studies, the differences between mouse and human also need to be considered. The objective of this study is to elucidate the different molecular mechanisms underlying oocyte maturation and fertilization between human and mouse.

Results

A comparative transcriptome analysis was performed to identify the differentially expressed genes and associated biological processes between human and mouse oocytes. In total, 8513 common genes, as well as 15,165 and 6126 uniquely expressed genes were detected in human and mouse MII oocytes, respectively. Additionally, the ratios of non-homologous genes in hu

SUBMITTER: Zhao ZH 

PROVIDER: S-EPMC7350670 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature