Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.

ABSTRACT:

Background

Dietary fish oil (DFO) has been identified as a micronutrient supplement with the potential to improve musculoskeletal health in old age. Few data are available for effects of DFO on muscle contractility, despite the significant negative impact of muscle weakness on age-related health outcomes. Accordingly, the effects of a DFO intervention on the contractile function and proteomic profile of adult and aged in an animal model of aging were investigated.

Methods

This preliminary study evaluated 14 adult (8 months) and 12 aged (22 months) male, Sprague-Dawley rats consuming a DFO-supplemented diet or a control diet for 8 weeks (7 adult and 6 aged/dietary group). Animal weight, food intake and grip strength were assessed at the start and end of the FO intervention. I

SUBMITTER: Russ DW 

PROVIDER: S-EPMC7350698 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature