Adenosine deaminase 2 activity negatively correlates with age during childhood.

ABSTRACT:

Background

Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as a biomarker is, however, limited by the absence of established ranges of ADA2 concentration and enzyme activity in the healthy population. It is known that ADA2 enzyme activity is lower in adults, but when (and why) this decline happens is not known. The purpose of this study was to establish normative ranges of ADA2 enzyme activity and protein concentration in the healthy pediatric population.

Methods

We modified a commercially available ADA2 enzyme activity assay to enable hig

SUBMITTER: Bowers SM 

PROVIDER: S-EPMC7350767 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature