Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19.

ABSTRACT:

Objective

To collate the evidence on the accuracy parameters of all available diagnostic methods for detecting SARS-CoV-2.

Methods

A systematic review with meta-analysis was performed. Searches were conducted in Pubmed and Scopus (April 2020). Studies reporting data on sensitivity or specificity of diagnostic tests for COVID-19 using any human biological sample were included.

Results

Sixteen studies were evaluated. Meta-analysis showed that computed tomography has high sensitivity (91.9% [89.8%-93.7%]), but low specificity (25.1% [21.0%-29.5%]). The combination of IgM and IgG antibodies demonstrated promising results for both parameters (84.5% [82.2%-86.6%]; 91.6% [86.0%-95.4%], respectively). For RT-PCR tests, rectal stools/swab, urine, and plasma were less sensitive

SUBMITTER: Boger B 

PROVIDER: S-EPMC7350782 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature