Transcriptome analysis reveals a reprogramming energy metabolism-related signature to improve prognosis in colon cancer.

ABSTRACT: Although much progress has been made to improve treatment, colon cancer remains a leading cause of cancer death worldwide. Metabolic reprogramming is a significant ability of cancer cells to ensure the necessary energy supply in uncontrolled proliferation. Since reprogramming energy metabolism has emerged as a new hallmark of cancer cells, accumulating evidences have suggested that metabolism-related genes may serve as key regulators of tumorigenesis and potential biomarkers. In this study, we analyzed a set of reprogramming energy metabolism-related genes by transcriptome analysis in colon cancer and revealed a five-gene signature that could significantly predict the overall survival. The reprogramming energy metabolism-related signature could distinguish patients into high-risk and low-r

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7350917 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature