Renomedullary Interstitial Cell Endothelin A Receptors Regulate BP and Renal Function.

ABSTRACT:

Background

The physiologic role of renomedullary interstitial cells, which are uniquely and abundantly found in the renal inner medulla, is largely unknown. Endothelin A receptors regulate multiple aspects of renomedullary interstitial cell function in vitro.

Methods

To assess the effect of targeting renomedullary interstitial cell endothelin A receptors in vivo, we generated a mouse knockout model with inducible disruption of renomedullary interstitial cell endothelin A receptors at 3 months of age.

Results

BP and renal function were similar between endothelin A receptor knockout and control mice during normal and reduced sodium or water intake. In contrast, on a high-salt diet, compared with control mice, the knockout mice had reduced BP; increased uri

SUBMITTER: Hu C 

PROVIDER: S-EPMC7351004 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature