Widespread diversity in the transcriptomes of functionally divergent limb tendons.

ABSTRACT:

Key points

Tendon is a hypocellular, matrix-rich tissue that has been excluded from comparative transcriptional atlases. These atlases have provided important knowledge about biological heterogeneity between tissues, and our study addresses this important gap. We performed measures on four of the most studied tendons, the Achilles, forepaw flexor, patellar and supraspinatus tendons of both mice and rats. These tendons are functionally distinct and are also among the most commonly injured, and therefore of important translational interest. Approximately one-third of the filtered transcriptome was differentially regulated between Achilles, forepaw flexor, patellar and supraspinatus tendons within either mice or rats. Nearly two-thirds of the transcripts that are expressed in anatomic

SUBMITTER: Disser NP 

PROVIDER: S-EPMC7351251 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature