Ontology highlight
ABSTRACT:
SUBMITTER: Treon SP
PROVIDER: S-EPMC7351339 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Treon Steven P SP Xu Lian L Guerrera Maria Luisa ML Jimenez Cristina C Hunter Zachary R ZR Liu Xia X Demos Maria M Gustine Joshua J Chan Gloria G Munshi Manit M Tsakmaklis Nicholas N Chen Jiaji G JG Kofides Amanda A Sklavenitis-Pistofidis Romanos R Bustoros Mark M Keezer Andrew A Meid Kirsten K Patterson Christopher J CJ Sacco Antonio A Roccaro Aldo A Branagan Andrew R AR Yang Guang G Ghobrial Irene M IM Castillo Jorge J JJ
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20200221 11
Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM), including <i>MYD88</i> (95%-97%), <i>CXCR4</i> (30%-40%), <i>ARID1A</i> (17%), and <i>CD79B</i> (8%-15%). Deletions involving chromosome 6q are common in patients with mutated <i>MYD88</i> and include genes that modulate NFKB, BCL2, Bruton tyrosine kinase (BTK), and apoptosis. Patients with wild-type <i>MYD88</i> WM show an increased risk of transformation and death and exhibit many mutatio ...[more]