Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever.

ABSTRACT:

Purpose of review

At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vector significantly decreased YF cases and reduced outbreaks to the tropical and subtropical forested regions of Africa and South America.

Recent findings

However, recent (2016) large outbreaks in Angola, Democratic Republic of Congo (DRC), and South-Eastern Brazil, where previously had been demarcated as low-risk regions, have highlighted the possibility of a rapidly changing epidemiology and the potential re-emergence of yellow fever virus (YFV). Furthermore, the first-ever importation of YFV into Asia has highlighted the potenti

SUBMITTER: Bifani AM 

PROVIDER: S-EPMC7351566 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature