Modification of the effects of prenatal manganese exposure on child neurodevelopment by maternal anemia and iron deficiency.

ABSTRACT:

Background

We evaluated: (1) associations of prenatal manganese (Mn) levels with child neurodevelopment at 4-6 years; (2) effect modification by maternal anemia and iron deficiency; and (3) sex-specific effects.

Methods

We measured blood Mn, hemoglobin, and serum ferritin in mothers at the second trimester, third trimester, and at birth, and in cord blood from a prospective birth cohort in Mexico City (n = 571). McCarthy Scales of Children's Abilities were measured at 4-6 years. Using linear regression, we estimated associations between prenatal Mn and neurodevelopment, examined anemia and iron deficiency as effect modifiers, and analyzed associations by child sex.

Results

No direct associations were observed between Mn, anemia, or iron deficiency and McCarthy Scales.

SUBMITTER: Kupsco A 

PROVIDER: S-EPMC7351595 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature