Evaluating the evidence for direct central nervous system invasion in patients infected with the nCOVID-19 virus.

ABSTRACT: The current nCOVID-19 pandemic is raising several questions in the approximately 25% of patients who present with neurological symptoms. While secondary brain injury from the systemic manifestations of the disease account for the majority of non-specific neurological symptoms that include headache, nausea, and progressive confusion, the question that remains unanswered is does the nCOVID-19 virus use the olfactory mucosa as a portal to directly invade the brain? A second question is how common does direct CNS invasion complicate the classical cardiorespiratory severe form of the disease? We know from previous studies that almost all members of the Corona virus family have neurotropism. We also know from the current pandemic that deteriorating consciousness and cerebrovascular accidents are

SUBMITTER: Lekgwara P 

PROVIDER: S-EPMC7351657 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature