Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19.

ABSTRACT:

Purpose

To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for treatment or prophylaxis of COVID-19 in adult humans.

Materials and methods

MEDLINE, PubMed, EMBASE and two pre-print repositories (bioRxiv, medRxiv) were searched from inception to 8th June 2020 for RCTs and nonrandomized studies (retrospective and prospective, including single-arm, studies) addressing the use of CQ/HCQ in any dose or combination for COVID-19.

Results

Thirty-two studies were included (6 RCTs, 26 nonrandomized, 29,192 participants). Two RCTs had high risk, two 'some concerns' and two low risk of bias (Rob2). Among nonrandomized studies with comparators, nine had high risk and five moderate risk of bias (ROBINS-I). Data synthesis was not possible. Low and moderate ri

SUBMITTER: Cortegiani A 

PROVIDER: S-EPMC7351664 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature