Value and choice as separable and stable representations in orbitofrontal cortex.

ABSTRACT: Value-based decision-making requires different variables-including offer value, choice, expected outcome, and recent history-at different times in the decision process. Orbitofrontal cortex (OFC) is implicated in value-based decision-making, but it is unclear how downstream circuits read out complex OFC responses into separate representations of the relevant variables to support distinct functions at specific times. We recorded from single OFC neurons while macaque monkeys made cost-benefit decisions. Using a novel analysis, we find separable neural dimensions that selectively represent the value, choice, and expected reward of the present and previous offers. The representations are generally stable during periods of behavioral relevance, then transition abruptly at key task events and be

SUBMITTER: Kimmel DL 

PROVIDER: S-EPMC7351792 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature