Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour.

ABSTRACT: RATIONALE:Reward-related impairments are common in major depressive disorder (MDD) and may contribute to the loss of interest in pleasurable activities. A novel approach to studying reward-related decision-making are effort-based tasks; however, direct comparisons between delayed-onset and rapid-acting antidepressants (ADs) have not yet been carried out. OBJECTIVES:To investigate the effects of conventional delayed-onset ADs versus rapid-acting ADs, ketamine and scopolamine, on effort-related choice behaviour. METHODS:Female Lister hooded rats were trained in an operant effort for reward task (EfRT) where animals choose between working for a high value-high effort reward and consuming low value-low effort chow. Using a within-subject study design, animals were then tested following acute t

SUBMITTER: Griesius S 

PROVIDER: S-EPMC7351874 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature