Associations of prenatal urinary phthalate exposure with preterm birth: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study.

ABSTRACT:

Objectives

To examine the relation between prenatal urinary phthalate metabolite concentrations and preterm birth (PTB).

Methods

The data were drawn from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian cohort of 1857 pregnant women enrolled between 2008 and 2011. We quantified urinary concentrations of 7 phthalate metabolites that were detected in > 70% of urine samples collected during the first trimester. Gestational age was obtained from either the last menstrual period or early ultrasound. We used Cox proportional hazard models to examine the associations of urinary phthalate metabolite concentrations, plus the molar sum of di-2-ethylhexyl phthalate metabolites (∑DEHP), with time to delivery before 37 weeks of gestation. We also exam

SUBMITTER: Hu JMY 

PROVIDER: S-EPMC7351891 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature