Expression profile of microRNAs in the testes of patients with Klinefelter syndrome.

ABSTRACT: Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy. A distinctive characteristic of KS is oligozoospermia. Despite multiple studies that have described the natural history of the degenerative process of germ cells in patients with KS, the molecular mechanisms that initiate this process are not well characterized. MicroRNA (miRNA)-mediated post-transcriptional control mechanisms have been increasingly recognized as important regulators of spermatogenesis; however, only a few studies have evaluated the role of miRNAs in the gonadal failure of these patients. Here, we describe a differential expression profile for the miRNAs in testicular tissue samples taken from KS patients. We analysed testicular tissue samples from 4 KS patients and 5 control patients (obstructive azoo

SUBMITTER: Ibarra-Ramirez M 

PROVIDER: S-EPMC7351945 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature