Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals.

ABSTRACT:

Background

Cure from chronic hepatitis C virus (HCV) infection is readily achievable with direct-acting antivirals (DAA), but little is known about optimal management after treatment. Weight gained after DAA treatment may mitigate benefits or increase risk for liver disease progression. As the single largest sample of HCV-infected individuals receiving DAA treatment in the United States, the Veterans Affairs (VA) Birth Cohort is an ideal setting to assess weight gain after DAA treatment.

Methods

We performed a prospective study of patients dispensed DAA therapy from January 2014 to June 2015. Weight change was calculated as the difference in weight from sustained virologic response (SVR) determination to 2 years later. Demographic, weight, height, prescription, laboratory, a

SUBMITTER: Do A 

PROVIDER: S-EPMC7352003 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature