Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases.

ABSTRACT: It has been reported that uterine fibroids (UFs) may increase the risk of endometrial carcinoma (EC) with the underlying mechanism largely unknown. Here, we explore whether UF could be an influential factor for EC. We have collected and analyzed clinical data from 4537 Chinese patients to study the co-incidence of UF and EC. Then, a large-scale literature-based data mining was conducted to identify genes implicated as UF downstream regulating targets and EC upstream regulators. In addition, a meta-analysis has been conducted for each of the EC-specific genes, using six independent UF expression datasets. The meta-analysis results, together with literature-based pathway analysis, were used to explore the potential explanation of the clinical data. Our results showed that the incidence rate

SUBMITTER: Qiao L 

PROVIDER: S-EPMC7352044 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature