Biliary Microbiota and Bile Acid Composition in Cholelithiasis.

ABSTRACT:

Background

A functional interplay between BAs and microbial composition in gut is a well-documented phenomenon. In bile, this phenomenon is far less studied, and with this report, we describe the interactions between the BAs and microbiota in this complex biological matrix. Methodology. Thirty-seven gallstone disease patients of which twenty-one with Opisthorchis felineus infection were enrolled in the study. The bile samples were obtained during laparoscopic cholecystectomy for gallstone disease operative treatment. Common bile acid composition was measured by LC-MS/MS. Gallbladder microbiota were previously analyzed with 16S rRNA gene sequencing on Illumina MiSeq platform. The associations between bile acid composition and microbiota were analyzed.

Results

Bi

SUBMITTER: Petrov VA 

PROVIDER: S-EPMC7352139 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature