Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives.

ABSTRACT: Testicular germ cell tumors share a marked sensitivity to cisplatin, contributing to their overall good prognosis. However, a subset of patients develop resistance to platinum-based treatments, by still-elusive mechanisms, experiencing poor quality of life due to multiple (often ineffective) interventions and, eventually, dying from disease. Currently, there is a lack of defined treatment opportunities for these patients that tackle the mechanism(s) underlying the emergence of resistance. Herein, we aim to provide a multifaceted overview of cisplatin resistance in testicular germ cell tumors, from the clinical perspective, to the pathobiology (including mechanisms contributing to induction of the resistant phenotype), to experimental models available for studying this occurrence. We provid

SUBMITTER: Lobo J 

PROVIDER: S-EPMC7352163 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature