Cannabis, the Endocannabinoid System and Immunity-the Journey from the Bedside to the Bench and Back.

ABSTRACT: The Cannabis plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid system. Cannabinoids affect the nervous system and play significant roles in the regulation of the immune system. While Cannabis is not yet registered as a drug, the potential of cannabinoid-based medicines for the treatment of various conditions has led many countries to authorize their clinical use. However, the data from basic and medical research dedicated to medical Cannabis is currently limited. A variety of pathological conditions involve dysregulation of the immune system. For example, in cancer, immune surveillance and cancer immuno-editing result in immune tolerance. On the other hand, in autoimmune diseases increase

SUBMITTER: Almogi-Hazan O 

PROVIDER: S-EPMC7352399 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature