Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword.

ABSTRACT: Cellular senescence was first described as a physiological tumor cell suppressor mechanism that leads to cell growth arrest with production of the senescence-associated secretory phenotype known as SASP. The main role of SASP in physiological conditions is to attract immune cells to clear senescent cells avoiding tumor development. However, senescence can be damage-associated and, depending on the nature of these stimuli, additional types of senescence have been described. In the context of cancer, damage-associated senescence has been described as a consequence of chemotherapy treatments that were initially thought of as a tumor suppressor mechanism. However, in certain contexts, senescence after chemotherapy can promote cancer progression, especially when immune cells become senescent an

SUBMITTER: Battram AM 

PROVIDER: S-EPMC7352478 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature