Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer.

ABSTRACT: Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in many countries. HPV-positive HNSCC mostly arise in the oropharynx and are characterized by an enhanced sensitivity towards radiotherapy and a favorable prognosis. To identify molecular differences between both entities on the protein level, we conducted a mass spectrometric comparison of eight HPV-positive and nine HPV-negative oropharyngeal tumors (OPSCC). Overall, we identified 2051 proteins, of which 31 were found to be differentially expressed. Seventeen of these can be assorted to three functional groups, namely DNA replication, nuclear architecture

SUBMITTER: Wurlitzer M 

PROVIDER: S-EPMC7352546 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature