DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer.

ABSTRACT: The Hedgehog (HH) pathway governs cell proliferation and patterning during embryonic development and is involved in regeneration, homeostasis and stem cell maintenance in adult tissues. The activity of this signaling is finely modulated at multiple levels and its dysregulation contributes to the onset of several human cancers. Ubiquitylation is a coordinated post-translational modification that controls a wide range of cellular functions and signaling transduction pathways. It is mediated by a sequential enzymatic network, in which ubiquitin ligases (E3) and deubiquitylase (DUBs) proteins are the main actors. The dynamic balance of the activity of these enzymes dictates the abundance and the fate of cellular proteins, thus affecting both physiological and pathological processes. Several E3

SUBMITTER: Bufalieri F 

PROVIDER: S-EPMC7352588 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature